Kalle Gehring, Alexey Yu Denisov, and Guennadi Dozlov
Department of Biochemistry,
McGill
University
Abstract:
The synthesis of proteins in the endoplasmic reticulum (ER) is limited by
the rate of protein folding and, in particular, the rate of correct
disulfide bond formation. This process is carried out by protein
disulfide isomerases, a family of ER proteins, which includes general
enzymes such as PDI that recognize unfolded proteins, and others that are
selective for specific proteins or classes of proteins. The talk will
present recent results from our laboratory on ERp57 and related protein
disulfide isomerases (PDIs) using a variety of biophysical techniques -
small-angle X-ray scattering (SAXS), X-ray crystallography and NMR
spectroscopy.
