Hiro Tsuruta
SSRL/SLAC, Stanford University
Abstract:
Synchrotron
beam line instrumentation optimized for solution x-ray scattering has
improved accessibility to high quality scattering data from typically weakly
scattering protein samples. Advanced computational methods are used to
obtain relatively low-resolution structures, which are often very useful to
answer many important questions about molecular mechanism, complementing the
atomic-resolution studies that are necessary to understand the "chemistry"
behind their functions. This talk will review some of the computational and
experimental techniques. Recent structural studies on hard-to-crystallize
protein assemblies will be presented. The second part of the talk will be
devoted to time-resolved structural studies on allosteric transition and
virus/phage maturation to illustrate highly cooperative molecular mechanism
built into protein assemblies.
2008 Run
Nov 19th - Dec 22nd
