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2017  May 17 - Jun 29

2017  Nov 1 - Dec 21

 

Biomolecules in Motion

 

Date: June 8
Local organizers: Richard Gillilan, Marian Szebenyi
Outside Organizer: Nozomi Ando (Princeton University)
 

 

This workshop focuses on motion of biomolecules (proteins, nucleic acids, complexes) which occurs as they perform their functions. “Motion” includes conformational changes, ranging from large domain “hinging” motions to relatively small loop motions (e.g. to allow and deny access to an active site); oligomerization changes; interaction with partner molecules.

Speakers: Philip Anfinrud (National Institutes of Health), Christopher Kupitz (University of Wisconsin), Lee Makowski (Northeastern University), Steve Meisburger (Princeton University), Sarah Perry (University of Massachusetts Amherst), Lois Pollack (Cornell University), Alessandro Spilotros (European Molecular Biology Laboratory), Henry van den Bedem (Stanford Synchrotron Radiation Lightsource)

 

Talks & Abstracts • PSB Floorplan • Participants

 

Wednesday, June 8   -   Clark Hall, Room 247

8:00

Registration, network, coffee, etc.

Biomolecules in Motion - Part I   Watch YouTube Live

8:20

Welcome, workshop goals

Marian Szebenyi (Director, MacCHESS)

8:30

Intro: planned CESR/CHESS upgrades

Joel Brock (Director, CHESS)

8:40

Talk #1: "Protein function depends on motion.. The challenge is characterizing motion..."

Lee Makowski (Northeastern University)

9:00

Talk #2: "New Opportunities at Pulsed X-ray Sources"

Christopher Kupitz (University of Wisconsin)

9:30

Talk #3: "Microfluidic Platforms for Time-Resolved Serial Protein Crystallography"

Sarah Perry (University of Massachusetts Amherst)

10:00

BREAK   -   Physical Sciences Building, West Pavillion

10:15

Talk #4: "Time-resolved SAXS/WAXS studies of proteins: from folding/unfolding to function"

Phil Anfinrud (National Institutes of Health)

10:45

Talk #5: Biological SAXS at the high brilliance beamline P12

Alessandro Spilotros (European Molecular Biology Laboratory)

11:15

Talk #6: "Watching macromolecules fold and function"

Lois Pollack (Cornell University)

11:45

Discussion

 

12:00

Group Photo

12:15

LUNCH - Clark Atrium

Biomolecules in Motion - Part II   Watch YouTube Live

1:15

Talk #7 "X-ray imaging of enzymes in motion"

Steve Meisburger (Princeton University)

1:45

Talk #8: "Resolving protein conformational dynamics from X-ray data"

Henry van den Bedem (Stanford Synchrotron Radiation Lightsource)

2:15

BREAK - Physical Sciences Building, West Pavillion

2:30

Beamline needs

Richard Gillilan (MacCHESS) (S/N at new beamlines) short talk, then discussion

3:00

Discussion: Design “model” science experiments

 

5:00

Summary and adjourn

 

6:00

DINNER - Wilson Lab Lower Lawn